ALK Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human cervical cancer Predicted cell location: Cell membrane, Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 650-664 amino acids of Human ALK tyrosine kinase receptor
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	anaplastic lymphoma receptor tyrosine kinase
Database Link	NP_004295 Entrez Gene 11682 MouseEntrez Gene 238 Human UniProt ID Q9UM73
Background	This gene encodes a receptor tyrosine kinase; which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain; an hydrophobic stretch corresponding to a single pass transmembrane region; and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged; mutated; or amplified in a series of tumours including anaplastic large cell lymphomas; neuroblastoma; and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene; which result in creation of multiple fusion genes in tumourigenesis; including ALK (chromosome 2)/EML4 (chromosome 2); ALK/RANBP2 (chromosome 2); ALK/ATIC (chromosome 2); ALK/TFG (chromosome 3); ALK/NPM1 (chromosome 5); ALK/SQSTM1 (chromosome 5); ALK/KIF5B (chromosome 10); ALK/CLTC (chromosome 17); ALK/TPM4 (chromosome 19); and ALK/MSN (chromosome X).
Synonyms	CD246; NBLST3
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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