PRCP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: SKOV3, A549 cells and human liver cancer tissue IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 46-317 amino acids of human prolylcarboxypeptidase (angiotensinase C)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	56 kDa
Gene Name	prolylcarboxypeptidase
Database Link	NP_005031 Entrez Gene 72461 MouseEntrez Gene 5547 Human UniProt ID P42785
Background	The protein encoded by this gene is a lysosomal prolylcarboxypeptidase; which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II; III and des-Arg9-bradykinin. The cleavage occurs at acidic pH; but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II; one of the substrates of this enzyme; in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms	HUMPCP; PCP
Reference Data
Protein Families	Druggable Genome, Protease, Transmembrane

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