AKAP12 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1768-1782 amino acids of human A kinase (PRKA) anchor protein 12
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	A-kinase anchoring protein 12
Database Link	NP_005091 Entrez Gene 9590 Human UniProt ID Q02952
Background	The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins; which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells; cultured fibroblasts; and osteosarcoma cells. It associates with protein kinases A and C and phosphatase; and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Synonyms	AKAP250; SSeCKS
Reference Data
Protein Families	Druggable Genome

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