NGAL (LCN2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 60-73 amino acids of human lipocalin 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lipocalin 2
Database Link	NP_005555 Entrez Gene 3934 Human UniProt ID P80188
Background	Iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. Binds iron through association with 2;5-dihydroxybenzoic acid (2;5-DHBA); a siderophore that shares structural similarities with bacterial enterobactin; and delivers or removes iron from the cell; depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor; leading to release of iron and subsequent increase of intracellular iron concentration. In contrast; association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore; iron chelation and iron transfer to the extracellular medium; thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis; while iron-free form decreases intracellular iron levels; inducing expression of the proapoptotic protein BCL2L11/BIM; resulting in apoptosis. Involved in innate immunity; possibly by sequestrating iron; leading to limit bacterial growth.
Synonyms	24p3; MSFI; NGAL
Reference Data
Protein Families	Secreted Protein

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