VGLL1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 2000-10000 WB positive control: 293T cells
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 62-75 amino acids of human vestigial like 1 (Drosophila)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29 kDa
Gene Name	vestigial like family member 1
Database Link	NP_057351 Entrez Gene 51442 Human UniProt ID Q99990
Background	The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. TDU interacted directly with the TEA domain family member; TEF1; and deletion of the Vg homology region abolished the interaction. The TDU-TEF1 dimer activated a reporter plasmid; and expression of TDU in Drosophila rescued loss of Vg function. The interaction was stronger in cardiac myocytes; suggesting a myocyte-specific factor may participate in the interaction. Vgll1 was weakly active in driving expression of a reporter gene from the mouse skeletal muscle alpha-actin promoter; and Vgll1 could partially reverse the inhibitory effect of TEF1 in this assay.
Synonyms	TDU; VGL1
Reference Data
Protein Families	Transcription Factors

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