AVEN Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Raji and Hela cells IHC: 25-100 Positive control: Human lung cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 339-353 amino acids of Human Apoptosis, caspase activation inhibitor
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	39 kDa
Gene Name	apoptosis and caspase activation inhibitor
Database Link	NP_065104 Entrez Gene 74268 MouseEntrez Gene 57099 Human UniProt ID Q9NQS1
Background	Aven binds to both Bcl-x(L) and the caspase regulator Apaf-1;which can supported that Bcl-x(L) inhibits cell death at a late (postmitochondrial) step in the death pathway.Identified in a yeast two-hybrid screen;Aven inhibited the proteolytic activation of caspases in a cell-free extract and suppressed apoptosis induced by Apaf-1 plus caspase-9. Expressing highly in the testis; ovary; and thymus .
Synonyms	PDCD12
Reference Data

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