AGBL2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: 293T cell IHC: 25-100 Positive control: Human gastric cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ATP/GTP binding protein-like 2
Database Link	NP_079059 Entrez Gene 79841 Human UniProt ID Q5U5Z8
Background	Metallocarboxypeptidase that may play a role in the processing of tubulin. Knockdown of AGBL2 results in a failure of the cell to detyrosinate the C-terminal EEY region of a-tubulin and indicates that, it is a candidate for the long sought after tubulin tyrosine carboxypeptidase important in regulation of microtubule dynamics. RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis and identify a novel area for therapeutic intervention.
Synonyms	CCP2
Reference Data
Protein Families	Druggable Genome

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