ENPP7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:1000-5000, WB: 1:500-2000, IHC: 1:50-200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 290-305 amino acids of Human ectonucleotide pyrophosphatase/phosphodiesterase 7
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52 kDa
Gene Name	ectonucleotide pyrophosphatase/phosphodiesterase 7
Database Link	NP_848638 Entrez Gene 238011 MouseEntrez Gene 303729 RatEntrez Gene 339221 Human UniProt ID Q6UWV6
Background	Ectonucleotide pyrophosphatase/phosphodiesterase family member 7?(E-NPP 7) also known as?alkaline sphingomyelin phosphodiesterase?(Alk-SMase) or?intestinal alkaline sphingomyelinase?is an?enzyme?that in humans is encoded by the?ENPP7?gene. Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. Inhibited in a dose dependent manner by ATP; imidazole; orthovanadate and zinc ion. Not inhibited by ADP; AMP and EDTA. Detected in the colon (at protein level). Expressed in the duodenum; jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus; stomach and colon.
Synonyms	339221; ALK-SMase; E-NPP 7; NPP-7; NPP7
Reference Data
Protein Pathways	Metabolic pathways, Sphingolipid metabolism

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