Telomerase reverse transcriptase (TERT) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human mucinous type of soft tissue sarcoma tissue lysate IHC: 100-300 Positive control: Human colorectal cancer Predicted cell location: Nucleus and Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 1120-1132 amino acids of human telomerase reverse transcriptase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	telomerase reverse transcriptase
Database Link	NP_937986 Entrez Gene 7015 Human UniProt ID O14746
Background	Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity; encoded by this gene; and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence; as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair; since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Synonyms	EST2; hEST2; TCS1; telomerase catalytic subunit; telomerase reverse transcriptase; TP2; TRT
Reference Data
Protein Families	Druggable Genome

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