ANGPTL3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: A375 cell lysate IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 300 amino acids of Human Angiopoietin-related protein 3
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	54 kDa
Gene Name	angiopoietin like 3
Database Link	NP_055310 Entrez Gene 27329 Human UniProt ID Q9Y5C1
Background	The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver; and has the characteristic structure of angiopoietins; consisting of a signal peptide; N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins; and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.
Synonyms	ANG-5; ANGPT5; ANL3; FHBL2
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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