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ICOS Rabbit Polyclonal Antibody
CAT＃: TA321805S
Anti-ICOS Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1,280.00
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CNY 300.00
CNY 1,430.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 150-300 Positive control: Human breast cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 21-140 amino acids of human inducible T-cell co-stimulator |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | inducible T-cell costimulator |
| Database Link | |
| Background | The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling; immune responses; and regulation of cell proliferation.?Enhances all basic T-cell responses to a foreign antigen; namely proliferation; secretion of lymphokines; up-regulation of molecules that mediate cell-cell interaction; and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2; but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. |
| Synonyms | AILIM; CD278; CVID1 |
| Reference Data | |
| Protein Families | Secreted Protein, Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Primary immunodeficiency, T cell receptor signaling pathway |
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