FRA1 (FOSL1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela and Jurkat cells IHC: 50-200 Positive control: Human gastric cancer Predicted cell location: nucleus
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 2-16 amino acids of Human FOS-like antigen 1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29 kDa
Gene Name	FOS like 1, AP-1 transcription factor subunit
Database Link	NP_005429 Entrez Gene 25445 RatEntrez Gene 8061 Human UniProt ID P15407
Background	Fos-related antigen 1 is a protein that in humans is encoded by the FOSL1 gene. The Fos gene family consists of 4 members: FOS; FOSB; FOSL1; and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family; thereby forming the transcription factor complex AP-1. As such; the FOS proteins have been implicated as regulators of cell proliferation; differentiation; and transformation. FOSL1 has been shown to interact with USF1 (human gene) and C-jun.
Synonyms	FRA; fra-1; FRA1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Wnt signaling pathway

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