NOTCH4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-50 Positive control: Human esophagus cancer Predicted cell location: Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from C' 1989-2003 amino acids of Human notch 4
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	notch 4
Database Link	NP_004548 Entrez Gene 4855 Human UniProt ID Q99466
Background	This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats; and an intracellular domain consisting of multiple; different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia; notch interaction with its cell-bound ligands (delta; serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human; but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network; and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands; and may play a role in vascular; renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
Synonyms	INT3
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Dorso-ventral axis formation, Notch signaling pathway

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