Beclin 1 (BECN1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse brain tissue, 293T cell lysates IHC: 50-100 Positive control: Human prostate cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 50-65 amino acids of Human beclin 1, autophagy related
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	beclin 1
Database Link	NP_003757 Entrez Gene 56208 MouseEntrez Gene 114558 RatEntrez Gene 8678 Human UniProt ID Q14457
Background	Beclin-1 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 is also known as autophagy-related gene (Atg) 6. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K); also named Vps34; which are participates in the regulation of autophagy and has an important role in development; tumorigenesis; and neurodegeneration. Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus. Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and KIAA0226/Rubicon; or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for BECN1-binding.
Synonyms	ATG6; beclin1; VPS30
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Regulation of autophagy

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