SSB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Nucleus
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 100-105 amino acids of human Sjogren syndrome antigen B (autoantigen La)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Sjogren syndrome antigen B
Database Link	NP_003133 Entrez Gene 20823 MouseEntrez Gene 81783 RatEntrez Gene 6741 Human UniProt ID P05455
Background	The protein encoded by this gene is involved in diverse aspects of RNA metabolism; including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion; processing 5' and 3' ends of pre-tRNA precursors; acting as an RNA chaperone; and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus.
Synonyms	La; LARP3; SSB
Reference Data
Protein Families	Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Systemic lupus erythematosus

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