Parathyroid hormone related protein (PTHLH) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 25-100 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 37-177 amino acids of human parathyroid hormone-like hormone
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	parathyroid hormone-like hormone
Database Link	NP_002811 Entrez Gene 19227 MouseEntrez Gene 24695 RatEntrez Gene 5744 Human UniProt ID P12272
Background	The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone; PTHR1; is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites; in-frame and downstream of the initiator AUG codon; to give rise to nuclear forms of this hormone.
Synonyms	BDE2; HHM; PLP; PTHR; PTHRP
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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