MEK6 (MAP2K6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse muscle tissue IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 31-297 amino acids of human mitogen-activated protein kinase kinase 6
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	37 kDa
Gene Name	mitogen-activated protein kinase kinase 6
Database Link	NP_002749 Entrez Gene 26399 MouseEntrez Gene 5608 Human UniProt ID P52564
Background	This gene encodes a member of the dual specificity protein kinase family; which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases; also known as extracellular signal-regulated kinases (ERKs); act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway; this gene is involved in many cellular processes such as stress induced cell cycle arrest; transcription activation and apoptosis.
Synonyms	MAPKK6; MEK6; MKK6; PRKMK6; SAPKK-3; SAPKK3
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Amyotrophic lateral sclerosis (ALS), Fc epsilon RI signaling pathway, GnRH signaling pathway, MAPK signaling pathway, Toll-like receptor signaling pathway

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