PDK2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Mouse heart tissue IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Mitochondrion matrix, Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 10-24 amino acids of human pyruvate dehydrogenase kinase, isozyme 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	46 kDa
Gene Name	pyruvate dehydrogenase kinase 2
Database Link	NP_002602 Entrez Gene 18604 MouseEntrez Gene 81530 RatEntrez Gene 5164 Human UniProt ID Q15119
Background	This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase; down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms	PDHK2; PDKII
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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