MMP15 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Mouse stomach, heart and liver tissue, HT-29 cells
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 300 amino acids of human matrix metallopeptidase 15 (membrane-inserted)matrix metallopeptidase 15 (membrane-inserted)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	76 kDa
Gene Name	matrix metallopeptidase 15
Database Link	NP_002419 Entrez Gene 17388 MouseEntrez Gene 4324 Human UniProt ID P51511
Background	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes; such as embryonic development; reproduction; and tissue remodeling; as well as in disease processes; such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However; the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
Synonyms	MT2-MMP; MTMMP2; SMCP-2
Reference Data
Protein Families	Druggable Genome, Protease, Transmembrane

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