MC1 Receptor (MC1R) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 301-315 amino acids of human melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	melanocortin 1 receptor
Database Link	NP_002377 Entrez Gene 17199 MouseEntrez Gene 4157 Human UniProt ID Q01726
Background	This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein; a seven pass transmembrane G protein coupled receptor; controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production; which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color; providing evidence that this gene is an important component in determining normal human pigment variation.
Synonyms	CMM5; MSH-R; SHEP2
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Melanogenesis, Neuroactive ligand-receptor interaction

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