CDC6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:1000-5000, WB: 1:200-1000, IHC: 1:25-100
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 18-32 amino acids of human cell division cycle 6 homolog (S. cerevisiae)
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	63 kDa
Gene Name	cell division cycle 6
Database Link	NP_001245 Entrez Gene 23834 MouseEntrez Gene 360621 RatEntrez Gene 990 Human UniProt ID Q99741
Background	The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6; a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1; but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
Synonyms	CDC18L; HsCDC6; HsCDC18
Reference Data
Protein Pathways	Cell cycle

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