Retinoic Acid Receptor alpha (RARA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human thyroid cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 200-419 amino acids of human retinoic acid receptor, alpha
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	retinoic acid receptor alpha
Database Link	NP_000955 Entrez Gene 19401 MouseEntrez Gene 5914 Human UniProt ID P10276
Background	This gene represents a nuclear retinoic acid receptor. The encoded protein; retinoic acid receptor alpha; regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development; differentiation; apoptosis; granulopoeisis; and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
Synonyms	NR1B1; RAR
Reference Data
Protein Families	Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
Protein Pathways	Acute myeloid leukemia, Pathways in cancer

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