Factor X (F10) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 200-1000 WB positive control: A549 cells
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 235-488 amino acids of human coagulation factor X
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55 kDa
Gene Name	coagulation factor X
Database Link	NP_000495 Entrez Gene 14058 MouseEntrez Gene 29243 RatEntrez Gene 2159 Human UniProt ID P00742
Background	This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains; while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway); or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va; Ca+2; and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency; a hemorrhagic condition of variable severity.
Synonyms	FX; FXA
Reference Data
Protein Families	Druggable Genome, Protease, Transmembrane
Protein Pathways	Complement and coagulation cascades

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