PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: J116]

Specifications

Product Data
Clone Name	J116
Applications	FC
Recommend Dilution	IHC, Functional Assay, IP, WB
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	programmed cell death 1
Database Link	NP_005009 Entrez Gene 5133 Human UniProt ID Q15116
Background	The J116 monoclonal antibody reacts with the human PD-1 (programmed death-1), a 55 kDa member of the immunoglobulin superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease. PD-1 is expressed predominantly on activated T and B lymphocytes. Two novel members of the B7 family have been identified as the PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Binding of the J116 monoclonal antibody inhibits PD-1 signal transduction, however, it does not block binding of the ligand PD-L1.
Synonyms	CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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