CD1 (CD1D) Mouse Monoclonal Antibody [Clone ID: 51.1]

Specifications

Product Data
Clone Name	51.1
Applications	FC
Recommend Dilution	Flow, IHC, IP
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration	lot specific
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD1d molecule
Database Link	NP_001757 Entrez Gene 912 Human UniProt ID P15813
Background	The monoclonal antibody 51.1 reacts with human CD1d, a member of the CD1 family with similarity to the non-polymorphic MHC Class I-like molecules. CD1d is a highly conserved single transmembrane receptor of the Immunoglobulin Superfamily. CD1d can associate with beta-microglobulin another feature showing similarity to MHC class I molecules, but can also exist as a nonglycosylated protein not in association with beta microglobulin. This suggests different control mechanisms for presenting glycolipid containing molecules to CD1d reactive NKT cells. Expression of CD1d is found on B cells of the periphery, in resting monocytes and cortical thymocytes. On intestinal epithelial cells (IEC) expression is polarized. Expression can also be found at low levels intracellularly in hepatocytes. In HCV (hepatitis C virus) livers, CD1d is highly expressed compared to normal controls.
Synonyms	CD1A; R3; R3G1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Hematopoietic cell lineage

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