C6ORF173 (CENPW) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.5 - 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	CENPW antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human CENPW.
Formulation	CENPW Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CENPW Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	9.9 kDa
Gene Name	centromere protein W
Database Link	NP_001012525 Entrez Gene 66311 MouseEntrez Gene 689399 RatEntrez Gene 387103 Human UniProt ID Q5EE01
Background	CENPW Antibody: CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.
Synonyms	C6orf173; CENP-W; CUG2
Reference Data

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