SHISA4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	SHISA4 antibody was raised against a 15 amino acid peptide near the center of human SHISA4 .
Formulation	SHISA4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SHISA4 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 22 kDa; Observed: 24 kDa
Gene Name	shisa family member 4
Database Link	NP_937792 Entrez Gene 77552 MouseEntrez Gene 149345 Human UniProt ID Q96DD7
Background	SHISA4 Antibody: SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
Synonyms	C1orf40; TMEM58
Reference Data
Protein Families	Transmembrane

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