LZTS2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	LZTS2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human LZTS2.
Formulation	LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	LZTS2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	leucine zipper, putative tumor suppressor 2
Database Link	NP_115805 Entrez Gene 226154 MouseEntrez Gene 84445 Human UniProt ID Q9BRK4
Background	LZTS2 Antibody: The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.
Synonyms	LAPSER1
Reference Data
Protein Families	Druggable Genome

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