ECRG4 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	ECRG4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human ECRG4.
Formulation	ECRG4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ECRG4 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	chromosome 2 open reading frame 40
Database Link	NP_115787 Entrez Gene 84417 Human UniProt ID Q9H1Z8
Background	ECRG4 Antibody: The esophageal cancer-related gene 4 (ECRG4), also known as Augurin, was identified through differential display screening between esophageal cancer and normal tissue. Hypermethylation of CpG sites in the ECRG4 promoter correlate with ECRG4 downregulation in numerous esophageal squamous cell carcinoma tissues.. In transfected cells, overexpression of ECRG4 induced G1 arrest, dephosphorylation of Rb and decreased expression of cyclins D1 and D3. Increased expression of ECRG4 in aged mouse brain is observed compared with young mouse brain. The increased ECRG4 level was accompanied by elevated senescence-associated acidic beta-galactosidase activity, suggesting that ECRG4 is involved in cellular differentiation and senescence.
Synonyms	ECRG4
Reference Data
Protein Families	Secreted Protein, Transmembrane

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