PAPP A2 (PAPPA2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PLAC3 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human PLAC3.
Formulation	PLAC3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PLAC3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	pappalysin 2
Database Link	NP_064714 Entrez Gene 23850 MouseEntrez Gene 680415 RatEntrez Gene 364027 RatEntrez Gene 60676 Human UniProt ID Q9BXP8
Background	PLAC3 Antibody: PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
Synonyms	PAPP-A2; PAPP-E; PAPPE; PLAC3
Reference Data
Protein Families	Protease, Secreted Protein

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.