SELK (SELENOK) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SELK antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human SELK.
Formulation	SELK Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SELK Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	10 kDa
Gene Name	selenoprotein K
Database Link	NP_067060 Entrez Gene 80795 MouseEntrez Gene 290549 RatEntrez Gene 58515 Human UniProt ID Q9Y6D0
Background	SELK Antibody: SELK is a selenoprotein, containing a selenocysteine residue at its active site. SELK is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. SELK can bind to proteins such as the ER-associated degradation (ERAD) components p97 ATPase, Derlin-1 and -2, and SelS as well as proteins in the oligosaccharyltransferase complex, suggesting that SELK may be involved in the Derlin-dependent ERAD of glycosylated misfolded proteins. SELK is also thought to be important in Ca2+ flux in immune cells, and is cleaved by m-calpain in resting macrophages. When these macrophages are activated through different Toll-like receptors, this cleavage is inhibited
Synonyms	HSPC030; HSPC297
Reference Data
Protein Families	Transmembrane

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