ZNF537 (TSHZ3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TSHZ3 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TSHZ3.
Formulation	TSHZ3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TSHZ3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	teashirt zinc finger homeobox 3
Database Link	NP_065907 Entrez Gene 243931 MouseEntrez Gene 308523 RatEntrez Gene 57616 Human UniProt ID Q63HK5
Background	TSHZ3 Antibody: The Teashirt zinc finger homeobox (TSHZ) family comprise a family of evolutionarily conserved transcription factors that, in Drosophila, are active in specific body parts for patterning, but whose function in vertebrates is less clear. In mice, the known three TSHZ proteins are expressed in distinct patterns in the developing and adult brain, suggesting that they play a role in the establishment of regional identity and specification of cell types within the brain. Both TSHZ3 and TSHZ1 have been found to interact with FE65, an adapter protein that binds to the amyloid protein precursor (APP) in neurons. Together with SET, a component of the inhibitor of acetyl transferase, and histone deacetylases, these proteins formed a gene-silencing complex whose target includes caspase-4. Recent experiments have also suggested this family of proteins may be involved in carcinogenesis.
Synonyms	TSH3; ZNF537
Reference Data
Protein Families	Transcription Factors

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