TET2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	TET2 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human TET2.
Formulation	TET2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TET2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tet methylcytosine dioxygenase 2
Database Link	NP_001120680 Entrez Gene 54790 Human UniProt ID Q6N021
Background	TET2 Antibody: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms, and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.
Synonyms	KIAA1546; MDS
Reference Data

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