CRIM1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	CRIM1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human Crim1.
Formulation	CRIM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CRIM1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cysteine rich transmembrane BMP regulator 1 (chordin-like)
Database Link	NP_057525 Entrez Gene 51232 Human UniProt ID Q9NZV1
Background	CRIM1 Antibody: CRIM1 (cysteine-rich motor neuron 1), a glycosylated type I transmembrane protein, plays a role in tissue development i.e. capillary formation and maintenance during angiogenesis. It contains an N-terminal IGF-binding protein-like motif and six von Willebrand-like cysteine-rich repeats (CRRs) in its extracellular domain. CRIM1 interacts with BMP4 and BMP7 via the CRRs and functions as an antagonist. CRIM1 is developmentally expressed in a number of tissues including the pancreas, kidney, placenta, brain and blood vessels. CRIM1 may participate in CNS and placental development by interacting with growth factors involved in motor neuron differentiation and survival.
Synonyms	CRIM-1; S52
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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