DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: 8B6]

Specifications

Product Data
Clone Name	8B6
Applications	IHC, WB
Recommend Dilution	WB: 1 - 2 mg/mL, ICC: 5 - 10 mg/mL
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
Formulation	DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	CD209 molecule
Database Link	NP_001138365 Entrez Gene 30835 Human UniProt ID Q9NNX6
Background	DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Synonyms	CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1
Reference Data
Protein Families	Druggable Genome

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