LRRTM2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	LRRTM2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LRRTM2.
Formulation	LRRTM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	LRRTM2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	leucine rich repeat transmembrane neuronal 2
Database Link	NP_056379 Entrez Gene 107065 MouseEntrez Gene 685472 RatEntrez Gene 26045 Human UniProt ID O43300
Background	LRRTM2 Antibody: The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development.
Synonyms	FLJ76283; FLJ99831
Reference Data
Protein Families	Transmembrane

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