IL17RA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	IL-17RA antibody was raised against an 18 amino acid peptide near the amino terminus of human IL-17RA.
Formulation	IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	IL-17RA Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Predicted Protein Size	Predicted: 95 kDa; Observed: 135 kDa
Gene Name	interleukin 17 receptor A
Database Link	NP_055154 Entrez Gene 16172 MouseEntrez Gene 312679 RatEntrez Gene 23765 Human UniProt ID Q96F46
Background	IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1). It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2). IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4). Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5).
Synonyms	CANDF5; CD217; CDw217; hIL-17R; IL-17RA; IL17R
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction

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