PHOX2B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	PHOX2B antibody was raised against a 15 amino acid synthetic peptide near the center of human PHOX2B.
Formulation	PHOX2B Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	PHOX2B Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	paired like homeobox 2b
Database Link	NP_003915 Entrez Gene 18935 MouseEntrez Gene 364152 RatEntrez Gene 8929 Human UniProt ID Q99453
Background	PHOX2B Antibody: PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
Synonyms	NBLST2; NBPhox; PMX2B
Reference Data

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