UNG Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	UNG2 antibody was raised against a 17 amino acid peptide near the amino terminus of human UNG2.
Formulation	UNG2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	UNG2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 34 kDa; Observed: 33 kDa
Gene Name	uracil DNA glycosylase
Database Link	NP_550433 Entrez Gene 7374 Human UniProt ID P13051
Background	UNG2 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promoters and alternative splicing. UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from DNA that arise through either misincorporation during replication or cytosine deamination. UNG2 can also be bound by the HIV-1 integrase and incorporated into the virion particle, suggesting that it is required to remove uracils from the viral genome. As the intrinsic antiviral protein APOBEC3G generates numerous uracils in the HIV genome during its replication, it may be that the UNG2 contributes to the APOBEC3G-mediated loss of infectivity by generating abasic sites in the viral genome.
Synonyms	DGU; HIGM4; HIGM5; UDG; UNG1; UNG2; UNG15
Reference Data

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