FOXO1 Rabbit Polyclonal Antibody
CNY 5,808.00
货期*
5周
规格
经常一起买 (4)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 1 ug/mL, ICC:4 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | FOXO1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human FOXO1. |
Formulation | FOXO1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | FOXO1 Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
Gene Name | forkhead box O1 |
Database Link | |
Background | FOXO1 Antibody: FOXO1, also known as FKHR or ForkHead in Rhabdomyosarcoma, is a 70 kDa protein which is a ubiquitously expressed member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In insulin-responsive tissues, stress or nutrient abundance triggers phosphorylation by PKB/AKT, blocking nuclear translocation and activity. Genetic mutations involving FOXO1A are a cause of alveolar rhabdomyosarcoma (RMS2). Recent studies link the anti-tumor activity of FOXO1 and the process of autophagy. |
Synonyms | FKH1; FKHR; FOXO1A |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Insulin signaling pathway, Pathways in cancer, Prostate cancer |
Documents
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