bcl 6 (BCL6) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	BCL6 antibody was raised against an 18 amino acid synthetic peptide near the center of human BCL6.
Formulation	BCL6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	BCL6 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	78 kDa
Gene Name	B-cell CLL/lymphoma 6
Database Link	NP_001124317 Entrez Gene 12053 MouseEntrez Gene 303836 RatEntrez Gene 604 Human UniProt ID P41182
Background	BCL6 Antibody: BCL6 was first identified as a proto-oncogene in diffuse large B cell lymphoma. BCL6, a transcriptional repressor, plays an important role in lymphomagenesis. It binds Stat recognition-like DNA elements and is required for affinity maturation of mature B cells in germinal centers and Th1/Th2 differentiation, a process that critically depends on BCL6-mediated transcriptional repression of p53. BCL6 is a pharmacological target for eradication of leukemia-initiating cells in chronic myeloid leukemia (CML).
Synonyms	BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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