Esrp1 Mouse Monoclonal Antibody [Clone ID: 27H12]

Specifications

Product Data
Clone Name	27H12
Applications	WB
Recommend Dilution	ELISA: 1:750,000, WB: 1:1000
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-Esrp-1 was produced by repeated immunizations of full length recombinant mouse Esrp-1 fusion protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	epithelial splicing regulatory protein 1
Database Link	NP_918944 Entrez Gene 207920 Mouse UniProt ID Q3US41
Synonyms	FLJ20171; RBM35A; RMB35A
Note	Epithelial splicing regulatory protein 1 (Esrp-1) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). EsrpP-1 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Reference Data

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