Esrp2 Mouse Monoclonal Antibody [Clone ID: 23A7.C9]

Specifications

Product Data
Clone Name	23A7.C9
Applications	WB
Recommend Dilution	ELISA: 1:750,000, WB: 1:1000
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Anti-Esrp-1/2 was produced by repeated immunizations of full length recombinant mouse Esrp-1 fusion protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	epithelial splicing regulatory protein 2
Database Link	NP_789808 Entrez Gene 77411 Mouse UniProt ID Q8K0G8
Synonyms	FLJ21918; FLJ22248; RBM35B
Note	Epithelial splicing regulatory protein-1 (Esrp-1) and Esrp-2 are mRNA splicing factors that regulate the formation of epithelial cell-specific isoforms. They specifically regulate the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 and -2 act by directly binding specific sequences in mRNAs. They bind the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Reference Data

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