PARP1 Mouse Monoclonal Antibody [Clone ID: 7A10]
CAT#: TA318859
Mouse monoclonal anti-PARP antibody, clone 7A10
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CNY 5,324.00
Cited in 1 publication. |
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 9,998.00
Specifications
Product Data | |
Clone Name | 7A10 |
Applications | FC, WB |
Recommend Dilution | WB: 1:500-2000, IF: 1:200-400 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A synthetic peptide corresponding to residues before the cleavage site of human PARP-1 was used as immunogen. The antibody only recognizes full-length form (p116) of PARP-1. |
Formulation | Supplied in 10 mM HEPES sodium (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol, and 0.03% sodium azide |
Purification | N/A |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | poly(ADP-ribose) polymerase 1 |
Database Link | |
Background | PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like Caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis. |
Synonyms | ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1; PARP; PARP-1; PPOL |
Reference Data | |
Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
Protein Pathways | Base excision repair |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Sundew plant, a potential source of anti-inflammatory agents, selectively induces G2/M arrest and apoptosis in MCF-7 cells through upregulation of p53 and Bax/Bcl-2 ratio
,Ghate, NB;Das, A;Chaudhuri, D;Panja, S;,
Cell Death Discovery
[PARP1]
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