beta Actin (ACTB) Mouse Monoclonal Antibody [Clone ID: 8H10]

CAT＃: TA310155

Mouse monoclonal anti-ACTB(beta Actin) antibody, Loading control

Datasheet
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CNY 3,060.00

货期*
5周
规格
    • 100 ug
Cited in 31 publications.

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Specifications

Product Data
Clone Name 8H10
Applications WB
Recommend Dilution WB 1:1000 - 1:10000
Reactivity Human, Mouse, Rat, Monkey, Dog
Host Mouse
Clonality Monoclonal
Immunogen Beta-actin N-terminal peptide-KLH conjugates
Formulation PBS, pH 7.4 with 0.05% sodium azide.
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name actin, beta
Database Link
Background Actins are highly conserved proteins that are involved in cell motility, structure and integrity, processes that are crucial for tissue development and the development of organism. The actin cytoskeleton is one of the principal drivers of cell motility and is capable of responding to complex signaling cascades. Recent evidence suggests that it may play key roles in regulating apoptosis and aging. beta actin is one of six different actin isoforms which have been identified. Like GAPDH, ?-actin is constitutively expressed at high levels in almost all tissues and cell lines making it ideal for use as a loading control marker in immunoblots.
Synonyms BRWS1; PS1TP5BP1
Reference Data
Protein Families ES Cell Differentiation/IPS
Protein Pathways Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Leukocyte transendothelial migration, Pathogenic Escherichia coli infection, Regulation of actin cytoskeleton, Tight junction, Vibrio cholerae infection, Viral myocarditis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (31)

The use of this Antibodies has been cited in the following citations:
Ox-LDL-Induced Vascular Smooth Muscle Cell Dysfunction Partly Depends on the Circ_0044073/miR-377-3p/AURKA Axis in Atherosclerosis. ,null, International heart journal ,PubMed ID 37005319 [ACTB]
Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma. ,null, Immunity ,PubMed ID 36563676 [ACTB]
The spleen physiologically clears Aβ, and splenectomy aggravates Alzheimer-type pathogenesis ,Yu, Z;Chen, D;Tan, C;Zeng, G;He, C;Bu, X;Wang, Y;, Research Square [ACTB]
Discovery of Klf2 interactors in mouse embryonic stem cells by immunoprecipitation-mass spectrometry utilizing exogenously expressed bait ,Seo, L;Kim, YI;Kim, H;Hyun, K;Kim, J;Lee, JE;, Biochimica et biophysica acta. Proteins and proteomics ,PubMed ID 34000451 [ACTB]
M2 macrophages-derived exosomal microRNA-501-3p promotes the progression of lung cancer via targeting WD repeat domain 82 ,Lei, J;Chen, P;Zhang, F;Zhang, N;Zhu, J;Wang, X;Jiang, T;, Cancer cell international ,PubMed ID 33546686 [ACTB]
Tropical lichen, Dirinaria consimilis, induces ROS-mediated activation of MAPKs and triggers caspase cascade mediated apoptosis in brain and cervical cancer cells ,Shendge, AK;Panja, S;Mandal, N;, Molecular and cellular biochemistry ,PubMed ID 33555513 [ACTB]
Potent anti-inflammatory Terminalia chebula fruit showed in vitro anticancer activity on lung and breast carcinoma cells through the regulation of Bax/Bcl-2 and caspase-cascade pathways ,Shendge, AK;Sarkar, R;Mandal, N;, J Food Biochem ,PubMed ID 33043490 [ACTB]
RIG-I Promotes Cell Death in Hepatocellular Carcinoma by Inducing M1 Polarization of Perineal Macrophages Through the RIG-I/MAVS/NF-κB Pathway ,Zhou, B;Li, C;Yang, Y;Wang, Z;, OncoTargets and therapy ,PubMed ID 32982277 [ACTB]
Olsalazine sodium increases renal urate excretion by modulating urate transporters in hyperuricemic animals ,Niu, Y;Yang, P;Li, H;Li, Q;Lin, H;Gao, L;Li, L;, Biol. Pharm. Bull. ,PubMed ID 32863294 [ACTB]
Salmonella enterica infection of murine and human enteroid-derived monolayers elicits differential activation of epithelial-intrinsic inflammasomes ,Holly, MK;Han, X;Zhao, EJ;Crowley, SM;Allaire, JM;Knodler, LA;Vallance, BA;Smith, JG;, Infect. Immun. ,PubMed ID 32284374 [ACTB]
ALS skin fibroblasts reveal oxidative stress and ERK1/2-mediated cytoplasmic localization of TDP-43 ,Romano, N;Catalani, A;Lattante, S;Belardo, A;Proietti, S;Bertini, L;Silvestri, F;Catalani, E;Cervia, D;Zolla, L;Sabatelli, M;Welshhans, K;Ceci, M;, Cellular Signalling ,PubMed ID 32126264 [ACTB]
Dimerization/oligomerization of the extracellular domain of the GLP-1 receptor and the negative cooperativity in its ligand binding revealed by the improved NanoBiT ,Song, X;Yu, Y;Shen, C;Wang, Y;Wang, N;, FASEB J. ,PubMed ID 31970836 [ACTB]
Antioxidant, anti‑inflammatory and anti‑fibrotic effects of Boswellia serrate gum resin in CCl4‑induced hepatotoxicity ,Eltahir, H;Fawzy, M;Mohamed, E;Alrehany, M;Shehata, A;Abouzied, M;, Exp Ther Med ,PubMed ID 32010304 [ACTB]
Identification of a clinical compound losmapimod that blocks Lassa virus entry ,Zhang, X;Yan, F;Tang, K;Chen, Q;Guo, J;Zhu, W;He, S;Banadyga, L;Qiu, X;Guo, Y;, Antiviral Res. ,PubMed ID 30953674 [ACTB]
Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice ,Wei, Y;Lao, XM;Xiao, X;Wang, XY;Wu, ZJ;Zeng, QH;Wu, CY;Wu, RQ;Chen, ZX;Zheng, L;Li, B;Kuang, DM;, Gastroenterology ,PubMed ID 30711627 [ACTB]
In Vitro Mechanistic Study of the Anti-inflammatory Activity of a Quinoline Isolated from Spondias pinnata Bark ,Ghate, NB;Chaudhuri, D;Panja, S;Singh, SS;Gupta, G;Lee, CY;Mandal, N;, J. Nat. Prod. ,PubMed ID 30215255 [ACTB]
Glyceraldehyde 3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells ,Sweeny, EA;Singh, AB;Chakravarti, R;Martinez-Guzman, O;Saini, A;Haque, MM;Garee, G;Dans, PD;Hannibal, L;Reddi, AR;Stuehr, DJ;, J. Biol. Chem. ,PubMed ID 30012884 [ACTB]
Effects of δ-tocotrienol on ochratoxin A-induced nephrotoxicity in rats ,Damiano, S;Navas, L;Lombari, P;Montagnaro, S;Forte, IM;Giordano, A;Florio, S;Ciarcia, R;, J. Cell. Physiol. ,PubMed ID 29775204 [ACTB]
Inhibition of microRNA‑16 protects mesenchymal stem cells against apoptosis ,Rui, J;Fang, S;Wang, Y;Lv, B;Yu, B;Li, S;, Mol Med Rep ,PubMed ID 29767235 [ACTB]
Hepatitis B virus X protein increases microRNA‑21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3‑kinase/protein kinase B signaling pathway. ,null, Molecular medicine reports ,PubMed ID 28339072 [ACTB]
Endogenous Nampt upregulation is associated with diabetic nephropathy inflammatory-fibrosis through the NF-κB p65 and Sirt1 pathway; NMN alleviates diabetic nephropathy inflammatory-fibrosis by inhibiting endogenous Nampt ,Chen, Y;Liang, Y;Hu, T;Wei, R;Cai, C;Wang, P;Wang, L;Qiao, W;Feng, L;, Exp Ther Med ,PubMed ID 29104634 [ACTB]
Reduced Klotho expression contributes to poor survival rates in human patients with ovarian cancer, and overexpression of Klotho inhibits the progression of ovarian cancer partly via the inhibition of systemic inflammation in nude mice ,Yan, Y;Wang, Y;Xiong, Y;Lin, X;Zhou, P;Chen, Z;, Molecular Medicine Reports ,PubMed ID 28259911 [ACTB]
Decreased Level of Klotho Contributes to Drug Resistance in Lung Cancer Cells: Involving in Klotho-Mediated Cell Autophagy ,Chen, T;Ren, H;Thakur, A;Yang, T;Li, Y;Zhang, S;Wang, T;Chen, M;, DNA Cell Biol. ,PubMed ID 27661766 [ACTB]
HMGB1 Enhances Drug Resistance and Promotes In Vivo Tumor Growth of Lung Cancer Cells ,Zheng, H;Chen, JN;Yu, X;Jiang, P;Yuan, L;Shen, HS;Zhao, LH;Chen, PF;Yang, M;, DNA Cell Biol. ,PubMed ID 27383136 [ACTB]
A Combination Therapy with Baicalein and Taxol Promotes Mitochondria-Mediated Cell Apoptosis: Involving in Akt/ß-Catenin Signaling Pathway ,Pan, Q;Xue, M;Xiao, SS;Wan, YJ;Xu, DB;, DNA Cell Biol. ,PubMed ID 27414207 [ACTB]
Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice ,Lu, YQ;He, XC;Zheng, P;, Mol. Hum. Reprod. ,PubMed ID 26769260 [ACTB]
Salmonella Virulence Factor SsrAB Regulated Factor Modulates Inflammatory Responses by Enhancing the Activation of NF-?B Signaling Pathway ,Lei, L;Wang, W;Xia, C;Liu, F;, J. Immunol. ,PubMed ID 26673132 [ACTB]
Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3a Downregulation ,Zhang, D;Wang, Y;Shi, Z;Liu, J;Sun, P;Hou, X;Zhang, J;Zhao, S;Zhou, BP;Mi, J;, Cell Rep ,PubMed ID 25732824 [ACTB]
[Human; WB]
Establish a dipeptidyl peptidases (DPP) 8/9 expressing cell model for evaluating the selectivity of DPP4 inhibitors ,Huan, Y;Jiang, Q;Liu, JL;Shen, ZF;, J Pharmacol Toxicol Methods ,PubMed ID 25464020 [ACTB]
[Human; WB]
The Angiotensin-converting enzyme 2/Angiotensin (1-7)/Mas axis Protects against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase Pathway ,Meng, Y;Li, T;Zhou, G;Chen, Y;Yu, CH;Pan, MX;Li, W;Li, Y;Zhang, WY;Li, X;, Antioxid. Redox Signal. ,PubMed ID 25089563 [ACTB]
[Rat; WB]
MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate-1 ,Li, Y;Huang, Q;Shi, X;Jin, X;Shen, L;Xu, X;Wei, W;, Chin. Med. J. 1410-6 127 8. April 2014 ,PubMed ID 24762580 [ACTB]
[Human; WB]

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