Haptoglobin (HP) Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.01-0.03ug/ml
Reactivity	Human
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence QCKNYYKLRTEGD, from the internal region of the protein sequence according to NP_005134.1; NP_001119574.1.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	haptoglobin
Database Link	NP_005134 Entrez Gene 3240 Human UniProt ID P00738
Background	This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms	BP; HP2ALPHA2; HPA1S
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein, Transmembrane

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