Dux4 (DUX4L1) Mouse Monoclonal Antibody [Clone ID: P2B1]

Specifications

Product Data
Clone Name	P2B1
Applications	IF, WB
Recommend Dilution	WB, IF, IHC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag
Formulation	TBS pH7.4, 50% glycerol
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	double homeobox 4 like 1
Database Link	NP_149418 Entrez Gene 22947 Human
Background	This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq]
Synonyms	DUX10
Reference Data

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