DUSP3 Rabbit Polyclonal Antibody
CAT#: TA308662
Rabbit Polyclonal antibody to DUSP3 (dual specificity phosphatase 3)
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CNY 6,281.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | IHC:1:100-1:1000; WB:1:500-1:3000 |
Reactivity | Human, Rhesus Monkey, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Recombinant fragment corresponding to a region within amino acids 1 and 185 of DUSP3 (Uniprot ID#P51452) |
Formulation | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
Concentration | lot specific |
Purification | Purified by antigen-affinity chromatography. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 20 kDa |
Gene Name | dual specificity phosphatase 3 |
Database Link | |
Background | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq] |
Synonyms | VHR |
Note | Seq homology of immunogen across species: Rhesus Monkey (100%) |
Reference Data | |
Protein Families | Druggable Genome, Phosphatase |
Protein Pathways | MAPK signaling pathway |
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