DUSP3 Rabbit Polyclonal Antibody

CAT#: TA308662

Rabbit Polyclonal antibody to DUSP3 (dual specificity phosphatase 3)



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CNY 6,281.00


货期*
5周

规格
    • 100 ul

Product images

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Recombinant protein of human dual specificity phosphatase 3 (DUSP3), 100 µg
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Specifications

Product Data
Applications IHC, WB
Recommend Dilution IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Human, Rhesus Monkey, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 185 of DUSP3 (Uniprot ID#P51452)
Formulation 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 20 kDa
Gene Name dual specificity phosphatase 3
Background The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq]
Synonyms VHR
Note Seq homology of immunogen across species: Rhesus Monkey (100%)
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways MAPK signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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