DCLK3 Rabbit Polyclonal Antibody
CNY 5,808.00
货期*
5周
规格
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 1 - 2 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | DCLK3 antibody was raised against a 14 amino acid peptide near the amino terminus of human DCLK3. |
Formulation | PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | doublecortin like kinase 3 |
Database Link | |
Background | DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. |
Synonyms | CLR; DCAMKL3; DCDC3C; DCK3 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
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