Cathelicidin (CAMP) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Cathelicidin antibody was raised against a 17 amino acid peptide near the carboxy terminus of the human Cathelicidin.
Formulation	PBS containing 0.02% sodium azide.
Concentration	lot specific
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	cathelicidin antimicrobial peptide
Database Link	NP_004336 Entrez Gene 12796 MouseEntrez Gene 316010 RatEntrez Gene 820 Human UniProt ID P49913
Background	One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.
Synonyms	CAP-18; CAP18; CRAMP; FALL-39; FALL39; HSD26; LL37
Reference Data
Protein Families	Secreted Protein, Transmembrane

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